At a glance
NHLBI Outstanding Investigator Award (OIA) (R35 Clinical Trial Optional) is a federal competitive grant from National Institutes of Health for the science & technology sector. Eligible applicants: Special district governments; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; County governments; Native American tribal governments (Federally recognized); Small businesse. The application deadline is April 28, 2027. Apply via the official listing at www.grants.gov.
- Amount
- See listing
- Deadline
- Apr 28, 2027
- Type
- Competitive
- Status
- Open
About this program
The purpose of the NHLBI Outstanding Investigator Award (OIA) is to promote scientific productivity and innovation by providing long-term support and increased flexibility to experienced Program Directors/Principal Investigators (PDs/PIs) who are currently PDs/PIs on at least two NHLBI R01-equivalent awards and whose outstanding record of research demonstrates their ability to make major contributions to heart, lung, blood and sleep (HLBS) research. The OIA is intended to support a research program, rather than a research project, by providing the primary and most likely sole source of NHLBI funding on individual grant awards. The OIA will support the research program of NHLBI-funded investigators for up to seven years. The OIA will provide investigators increased freedom to conduct research that breaks new ground or extends previous discoveries in new directions. It will also allow PDs/PIs to take greater risks and to pursue research that requires a longer timeframe. Research supported by the OIA must be within the scope of the NHLBI mission (https://www.nhlbi.nih.gov/about/mission-statement). It is anticipated that the OIA will: Provide a stable funding environment, thereby improving productivity and facilitating nimble, ambitious, creative research; Accelerate scientific innovation by enabling flexibility in pursuing new research directions as they arise, since PDs/PIs will not be bound to specific aims proposed in advance of the studies; Reduce the time researchers spend writing grant applications and managing multiple grant awards, thereby allowing more time to be devoted to conducting research; Facilitate commitment of PDs/PIs to research through increased stability of funding; and Enable PDs/PIs to devote more time and energy to mentoring students and junior scientists and providing scientific service.
Who can apply
Special district governments; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; County governments; Native American tribal governments (Federally recognized); Small businesses; Others (see text field entitled "Additional Information on Eligibility" for clarification); Public housing authorities/Indian housing authorities; Native American tribal organizations (other than Federally recognized tribal governments); State governments; Independent school districts; Private institutions of higher education; Public and State controlled institutions of higher education; For profit organizations other than small businesses; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; City or township governments. Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
How to apply
Apply through Grants.gov using funding opportunity number RFA-HL-26-002. Register your organization (SAM.gov + Grants.gov) before the deadline, then submit the application package listed in the official notice.
Apply at official sourceRelated grants
- NSF Astronomy and Astrophysics Postdoctoral Fellowships NSF · Up to $110K · Oct 15, 2026 Open
- NHLBI Career Transition Award for Intramural Postdoctoral Fellows and Research Trainees (K22 Independent Clinical Trial Not Allowed) NIH · See listing · Jul 12, 2027 Open
- Enhancing Mechanistic Research on Precision Probiotic Therapies (R33 Clinical Trial Optional) NIH · Up to $25K · Jun 2, 2027 Open
- Mind and Body Interventions to Restore Whole Person Health via Emotional Well-Being Mechanisms (R61/R33 Clinical Trial Required) NIH · See listing · Jun 7, 2028 Open