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Federal Forecasted GRANTS-GOV-361450

Functional Target Validation for Alzheimer's Disease-Related Dementias

National Institutes of Health (NIH) · Competitive grant · Science & Technology

At a glance

Functional Target Validation for Alzheimer's Disease-Related Dementias is a federal competitive grant from National Institutes of Health for the science & technology sector. Funding: 1800000. Eligible applicants: Private institutions of higher education; Native American tribal governments (Federally recognized); Small businesses; Native American tribal organizations (other than Federally recognized tribal governments); Independen. Applications are accepted on a rolling basis. Apply via the official listing at www.grants.gov.

Amount
$1.8M total
Deadline
Rolling
Type
Competitive
Status
Forecasted

About this program

The National Institute of Neurological Disorders and Stroke (NINDS) is interested in supporting ambitious research projects that propose comprehensive functional validation of newly identified therapeutic target candidates for Alzheimer’s Disease–Related Dementias (ADRD). A major barrier to the development of effective treatments for ADRD, as well as other complex central nervous system disorders, is the lack of well-validated targets that are clearly linked to disease mechanisms. Successful translation of basic discoveries into the clinic depends on the rigor of target validation and confidence in a causal relationship between modulation of a target and its functional physiological consequences relevant to treating or preventing disease. This initiative aims to de-risk subsequent translational research and accelerate the development of novel therapeutic strategies.NINDS believes that this initiative would be most appropriately supported by a phased award mechanism (for example, R61/R33).  In the initial phase, support would be provided for the development of customized technologies, models, and protocols to modulate the expression or activity of candidate targets and to assess their physiological consequences in relevant in vitro and in vivo disease models. Upon successful achievement of predefined, milestone-based technical feasibility and proof-of-concept criteria, projects would transition to the second phase focused on measuring and cross-validating the effects of target modulation across multiple experimental modalities and collaborating laboratories, in accordance with NIH rigor and reproducibility guidelines.Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop responsive projects and establish appropriate cross-disciplinary collaborations.

Who can apply

Private institutions of higher education; Native American tribal governments (Federally recognized); Small businesses; Native American tribal organizations (other than Federally recognized tribal governments); Independent school districts; Others (see text field entitled "Additional Information on Eligibility" for clarification); Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Public housing authorities/Indian housing authorities; City or township governments; Special district governments; Public and State controlled institutions of higher education; State governments; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; County governments; For profit organizations other than small businesses. Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions) are not allowed

How to apply

Apply through Grants.gov using funding opportunity number RFA-NS-26-034. Register your organization (SAM.gov + Grants.gov) before the deadline, then submit the application package listed in the official notice.

Apply at official source